Prednisolone is a synthetic adrenocortical steroid with strong glucocorticoid activity and minimal mineralocorticoid effects.
- Use only if benefits outweigh potential risks.
- Passes into breast milk; may affect infant growth and adrenal function.
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Pednisol is prescribed for a wide range of inflammatory, autoimmune, allergic, and endocrine conditions:
Fluid/electrolyte: Sodium/fluid retention, potassium loss, hypertension, CHF in predisposed patients.
Musculoskeletal: Weakness, osteoporosis, aseptic necrosis, fractures.
GI: Peptic ulcer, GI bleeding, pancreatitis.
Dermatologic: Fragile skin, poor wound healing, petechiae, erythema.
Neurological: Headache, vertigo, pseudotumor cerebri, seizures.
Endocrine: Cushingoid features, growth suppression, menstrual irregularities, glucose intolerance.
Ophthalmic: Cataracts, glaucoma, exophthalmos.
Metabolic: Negative nitrogen balance.
Adults
Nephrotic syndrome:
Initial: 2 mg/kg/day (max 80 mg/day) in 3–4 divided doses until proteinuria resolves for 3 consecutive days (max 28 days).
Then: 1–1.5 mg/kg every other day for 4 weeks.
Maintenance: 0.5–1 mg/kg every other day for 3–6 months.
Anti-inflammatory: 5–60 mg/day in 1–4 divided doses.
Acute asthma: 40–60 mg/day PO (single or divided) for 3–10 days.
Allergic conditions (tapering regimen):
Day 1: 10 mg (before breakfast), 5 mg (after lunch & dinner), 10 mg (bedtime)
Gradual dose reduction until Day 6: 5 mg (morning only).
Pediatrics
Asthma (Acute/Maintenance):
1 year: 10 mg q12h / every other day
1–4 years: 20 mg q12h / every other day
5–12 years: 30 mg q12h / every other day
≥12 years: 40 mg q12h / every other day
Anti-inflammatory / Immunosuppression: 0.05–2 mg/kg/day in 1–4 divided doses.
Reduced efficacy with aminoglutethimide, antacids, barbiturates, carbamazepine, griseofulvin, mitotane, phenylbutazone, phenytoin, primidone, and rifampin.
Risk of arrhythmia with digitalis if hypokalemia develops.
Use caution with immunizations during therapy.
Store in a cool, dry place away from light. Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.